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hepatocyte images: illustrations and micrographs. All credits and licenses listed.

Micrographs

Normal human liver: reticulin stain with zones labelled. Portal triad (Zone 1) to central vein (Zone 3). Hepatocyte plates outlined in reticulin fibres.

Normal human liver: reticulin stain with zones labelled. Portal triad (Zone 1) to central vein (Zone 3). Hepatocyte plates outlined in reticulin fibres.

Boyd A, Cain O, Chauhan A, Webb GJ · CC BY 4.0 · source

Macrovesicular steatosis in NAFLD/MASLD. Trichrome stain: large lipid vacuoles (white) displace hepatocyte nuclei; pericellular fibrosis in blue-green; central vein centre-right.

Macrovesicular steatosis in NAFLD/MASLD. Trichrome stain: large lipid vacuoles (white) displace hepatocyte nuclei; pericellular fibrosis in blue-green; central vein centre-right.

Nephron · CC BY-SA 3.0 · source

Steatohepatitis (MASH). Trichrome stain at high magnification: ballooned hepatocytes, microvesicular and macrovesicular steatosis, lobular inflammation, chicken-wire pericellular fibrosis.

Steatohepatitis (MASH). Trichrome stain at high magnification: ballooned hepatocytes, microvesicular and macrovesicular steatosis, lobular inflammation, chicken-wire pericellular fibrosis.

Nephron · CC BY-SA 3.0 · source

Illustrations

Classic lobule (Kiernan 1833) and Rappaport acinus (1954): zonal organization, vascular landmarks, and injury patterns by zone.

Classic lobule (Kiernan 1833) and Rappaport acinus (1954): zonal organization, vascular landmarks, and injury patterns by zone.

Illustration by hepato.site · CC0

Hepatocyte ultrastructure: nucleus, mitochondria, smooth and rough ER, glycogen, lipid droplets, bile canaliculus, space of Disse. Sources: Fawcett 1966; Bancroft & Gamble 7th ed.

Hepatocyte ultrastructure: nucleus, mitochondria, smooth and rough ER, glycogen, lipid droplets, bile canaliculus, space of Disse. Sources: Fawcett 1966; Bancroft & Gamble 7th ed.

Illustration by hepato.site · CC0

Hepatocyte zonation gradient from portal triad (Zone 1) to central vein (Zone 3): O2 gradient, Wnt gradient, metabolic programs by zone, and zone-specific pathology.

Hepatocyte zonation gradient from portal triad (Zone 1) to central vein (Zone 3): O2 gradient, Wnt gradient, metabolic programs by zone, and zone-specific pathology.

Illustration hepato.site; data after Jungermann K 1982 and Ramachandran P et al. 2026 · CC0

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